... monitoring his vital signs and maintaining them within tight ranges Anaesthesia from the beginning up to the end of surgery lasted 80 minutes Postoperative care, including fluid management and weaning ... 0.18 Transfusionof units of red blood cells 5.3 0.25 Debridement humerus, transfusionof unit of red blood cell 4.4 0.21 General anaesthesia to insertion of central venous line 3.9 0.18 Transfusion ... 0.18 Transfusionof unit of red blood cell 5.2 0.24 Sequestrectomy tibia, transfusionof units of red blood cells Debridement tibia, transfusionof units of red blood cells In addition to classical...
... trials now incorporate the expansion of http://www.jhoonline.org/content/1/1/19 one unit ofcordblood following the infusion of another unexpanded unit in a double cordblood transplant setting The ... significant increase in CBT for patientsin need of transplantation with matched unrelated allogeneic HSC This, coupled with the immediate availability ofcordblood units (CBU), has made cordblood ... risks of expansion Moreover, a recent study from Shah et al shows that alemtuzumab is effective in decreasing the incidence of GVHD without increasing the risk of relapse in pediatric patients...
... difference in the minimum value of haemoglobin during DrotAA and in the post-DrotAA period (Table 4) A larger proportion ofpatients required platelet transfusion during DrotAA infusion compared with ... use of packed red cell (PRC) and blood products inpatientswith acute kidney injury requiring RRT treated with DrotAA A further comparison of the outcome parameters was made during the DrotAA infusion ... analysis in a small number of patients; however, this is an area of practice that is clinically important and in which it is difficult for individual clinicians working in smaller centres to gain sufficient...
... together with interdisciplinary and international differences intransfusion preferences, should be taken into consideration in the planning of future studies This will help maximize clinician buy -in ... ongoing National Institutes of Health-sponsored phase II clinical trial in traumatic brain injury patients uses a PbtO2 threshold of 20 mmHg to initiate therapy [26] The clinical significance of ... monitoring in SAH patients report targeting higher Hb concentrations, especially inpatientswith DCI (mean Hb with multimodal monitoring, 8.82 g/dL (95% CI, 8.55 to 0.10); mean Hb without monitoring,...
... setting of more routine decompensated heart failure, and the effect milrinone in ischemic subset ofpatients deserves further investigation Conclusion Initiation of milrinone therapy inpatients ... studies examining natriuretic peptide levels and/or inflammatory markers during inotrope administration with inconsistent results [8-11] Adding complexity to this picture is data indicating that ... regarding the effect of milrinone on apoptosis markers, or whether high-sensitivity troponin may reveal sub-clinical cardiac injury due to inotrope initiation We sought to determine the effect of initiating...
... quality of life even before the fracture occur [29-32] The wrist patients have a modest decrease in health-focused quality of life within physical domain and scores in accordance with controls within ... analyses The values of the regression coefficients were interpreted according to Cohen's effect size index, in which coefficients in the range 0.2–0.5 are defined as indicating a small difference, ... or both of the total hip or lumbar spine L2–L4 was found in 33% of the wrist fracture patients, 59% of the hip fracture patients, and 16% of the controls The difference in frequency of osteoporosis...
... cause of hypoxemia in alcoholic patients [19] Moreover, in these series ofpatients none presented with dyspnea or clinical signs of hepatopulmonary syndrome These findings confirm previous clinical ... diagnosed occurring in chronic liver disease of all types and mainly in severe suffering patients [4, 9, 10, 11] Liver cirrhosis is often accompanied by arterial hypoxemia in the absence of cardiopulmonary ... arguing whether or not hypoxemia develops inpatientswith intrapulmonary vasodilatation [15, 16] In our study all ofpatientswith cirrhosis (Child-Pugh B and C) had hypoxemia Contradictory, according...
... number of CD4+CD28– T cells in each of these disease categories is shown in Table The frequency of CD4+CD28– T cells was 4.82% inpatientswith limited joint manifestations, 7.05% in those with ... joint involvement The lowest frequency of CD4+CD28– T cells was in RA patientswith limited joint manifestations Significantly higher numbers of CD28– lymphocytes were present inpatientswith ... thrombosis Clonal expansion of CD4+CD28– T cells has been found in the inflamed plaque of such patients [12] Table Frequency of CD4+CD28– T cells in control group and inpatientswith RA Subjects CD4+CD28–...
... targets of anti-TNF-α activity in RA, and may provide an insight into a new and interesting mechanism of action of anti-TNF-α mAbs in the control of inflammatory arthritis Competing interests ... N-formyl-1methionyl-l-leucyl-1-phenylalanine: analysis of single cell movement J Leukocyte Biol 1992, 52:630-636 Binder R, Kress A, Kan G, Herrmann K, Kirschfink M: Neutrophil priming by cytokines and vitamin D binding protein (Gc-globulin): ... initiation of treatment with leflunomide or methotrexate inpatientswith rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients Arthritis Rheum...
... other laboratory findings listed in Table None of the patientswith pSS had an increased level of CRP There was a tendency for increased numbers of IL-10-secreting PBMC inpatientswith pSS (p < ... al We examined serum levels of MIF inpatientswith pSS and the relation of these levels to clinical and laboratory findings In addition, we analysed associations of MIF concentrations with various ... elevated in our cohort, the increased MIF levels inpatientswith pSS cannot be explained by differences in the extent of acutephase response Hence, specific mechanisms of MIF induction in pSS remain...
... combined with parotid salivary output ofpatientswith head-and-neck malignancies treated with RT We found a deterioration of most of the QOL items after completion of radiotherapy compared with ... RT with curative intent were included in the study Other inclusion criteria were no previous RT or surgery of the parotid glands, no history of suffering from malignancies or other diseases of ... http://www.ro-journal.com/content/2/1/3 Table 2: Mean scores of the scales and single items of questionnaire for patientswith cancer of the head- and-neck treated with radiotherapy with or without surgery A significant outcome...
... with MTX, in combination with leflunomide, in combination with azathioprine, and with sulfasalazine), and azathioprine (2 patients) Nine patients received a combination of DMARD (8 patients received ... Vitamin D binding protein (Gc-globulin) Endocr Rev 1989, 10:294-307 18 Lind SE, Smith DB, Janmey PA, Stossel TP: Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from ... model of plasma gelsolin (pGSN) function in clearing actin from synovial joints of rheumatoid arthritis patientswith acute joint effusion (1) (pGSN) function in clearing actin from synovial joints...
... scleroderma and in 40% ofpatientswith diffuse SSc [5] High-resolution computed tomography detects ILD changes in 90% to 100% of SSc patients [2,5] ILD is associated with increased mortality inpatients ... data, CYC treatment inpatientswith SScrelated ILD does not appear to result in clinically significant improvement of pulmonary function Since none of the patients included in these studies were ... the drug inpatientswith SSc [28,29] The adverse events counted in our nine studies included two cases of hemorrhagic cystitis [17] and several cases of hematuria – one case in Valentini and...
... of the clinical centers specializing in the care of SSc patients participating in the network, but also ofpatients who are seen only once a year in a clinical center participating in the network ... College of Rheumatology criteria or the main symptoms of SSc, combined with another nonorgan-specific autoimmune disease or with the main symptoms of such a disease and, as a rule, with proof of characteristic ... College of Rheumatology, with the exception of higher rates of D-penicillamine use in SSc in North America (that is, 20% for skin involvement) Conclusion The present study is the first investigating...
... who demonstrated an increase in serum levels of these cytokines inpatientswith intermittent claudication The authors suggested that a high level of cytokines is indicative of some complications ... placed in tubes containing heparin for biochemical analysis, cytokine measurement and the isolation and culturing of monocytes Isolation of peripheral blood mononuclear cells Heparinized venous blood ... alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine ofpatients and control subjects are shown in Table Patients and control subjects presented levels within...
... reported inpatientswith bipolar I or II depression receiving quetiapine or inpatientswith bipolar I depression receiving olanzapine/ fluoxetine [21-23] They are also within the range of values ... olanzapine alone (versus 1.4-3.6 points for olanzapine alone in the studies included in this analysis) and 5.9-7.8 points when combined with fluoxetine [21] In the current analysis, olanzapine also ... were in line with those reported from the observed case analysis The efficacy of asenapine in treating depressive symptoms is supported by in vitro and in vivo preclinical findings Asenapine has...
... randomly assigned to of therapeutic doses of olanzapine LAI (N = 599) were included in these analyses Patients were 18 to 75 years of age with a diagnosis of schizophrenia according to the DSM-IV ... measures investigated included incidence of unsolicited treatment-emergent adverse events occurring in ≥5% ofpatients or with between-groups p
... utilization of coping strategies inpatientswith chronic pain when their pain is at a moderate level of intensity or greater The VPMI has two validated subscales: active coping and passive coping [24] ... explained 49% of variance in BASFI scores More specifically, each numerical increase (range of scores to 27, with higher numbers equaling more depression) in depression resulted in an increase of ... functional limitation in the final model, mirroring findings in other chronic arthritic conditions [19,24,29,31-34] Our findings are also consistent with a previous report linking helplessness to...
... honeycombing involving up to 25% of the lobe, 3honeycombing involving 25–49% of the lobe, 4- honeycombing involving 50–75% of the lobe, 5- honeycombing involving > 75% of the lobe for interstitial ... only in 16% of our cohort but in 50% ofpatientswith diffuse skin involvement, while moderate-severe restrictive lung disease occurred in 12% of the whole cohort and in 41.7% of the patientswith ... HRCT performed in 93 SSc patients ** BAL performed in 42 SSc patients giving their informed consent of the patients without (p = ns) IL-6 plasma levels were higher inpatientswith positive BAL...
... pointed out earlier, in order to demonstrate the clinical effectiveness of immunotherapy in severe sepsis and septic shock, a number of 120 patients is necessary to be included in each arm of ... Analyzing the data by means of definitions of sepsis and septic shock, and assuming the patients to be a uniform group, we cannot demonstrate the special subgroups ofpatientsin whom the administration ... effect of immunoglobulins could be shown Using such an approach, a beneficial effect of IgG immunotherapy in a special subgroup of septic patients has already been shown in the study by Dominioni...